Alkylation of Cellular Macromolecules by Reactive Metabolic Intermediate of DBCP
نویسندگان
چکیده
منابع مشابه
Alkylation of cellular macromolecules and target specificity of carcinogenic nitrosodialkylamines: metabolic activation by cytochromes P450 2B1 and 2E1.
The alkylation of DNA, RNA and protein by labeled metabolites of [alpha-14C]nitrosodimethylamine (NDMA), [alpha-14C]nitrosodipropylamine (NDPA) and [alpha-14C]nitrosodibutylamine (NDBA) was determined as a measure of the metabolic activation of these nitrosamine carcinogens in vitro using microsomes prepared from freshly isolated rat hepatocytes as well as in intact cells using primary cultured...
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ژورنال
عنوان ژورنال: Journal of Pesticide Science
سال: 1980
ISSN: 1348-589X,1349-0923
DOI: 10.1584/jpestics.5.45